A summary of these biotransformation mechanisms as related to Opaline® Dry Oxy™ capsules is expressed in Figure 1-1, which summarizes the proposed relationship between biotransformation, bioactiviation and toxicity of a xenobiotic as seen in the individuals having the disease Morgellon’s.
Analytical testing of Morgellon’s Individuals fiber, gels and other material specimens have been confirmed by advanced analytical testing (under Project: FMM) to be composed of nano composite materials as identified as parent compounds that have known metabolites and may be converted to a reactive intermediate or interact directly with the cellular organelle functions. Reactive intermediates can be detoxified and thus become metabolites that are eliminated.
Indeed, only a small portion of these reactive intermediates may become covalently bound to tissue macromolecules. In some cases, covalent binding may be viewed as a detoxification of a reactive metabolite. However, in such binding results in inactivation of a critical enzyme, depletion of important cellular antioxidants (i.e., GSH), formation of an antigenic determinate, cross linking of neuro filaments, and so on, toxicity may result as seen in Morgellon’s diseased individuals that participated in this study. The relationship between covalent binding of xenobiotics to cellular components and tissue injuries remain to be further established through further investigative research in this field of interest by the researchers.
In summation, as an Industrial Toxicologist/IH and Doctor of Integrative Medicine who has evaluated the toxicological effects of hazardous materials for 30 years, I would recommend Opaline® Dry Oxy™ capsules to my Morgellon’s individuals, Emergency Preparedness First Responders and the general public for a comprehensive approach to increasing the absorption of oxygen for cellular respiration and reduction of reactive intermediates from chemical exposures.
INTEGRATIVE HEALTH SYSTEMS, LLC
Dr. Hildegarde Staninger™, RIET-1
Industrial Toxicologist/IH & Doctor of Integrative Medicine
1. Bradford, Robert W. and Henry W. Allen. Oxidology: The Study of Reactive Oxygen Species (ROS) & Their Metabolism in Health and Disease, 2nd Edition. The Robert W. Bradford Foundation, Chula Vista, CA Chapter 2: Redoxology Principals. Page 57-58. © 1997
2. Evans, Scott and Hildegarde Sacarello. Ground Water Contamination through Electrophilic Neutrophilic Compounds and Their Genetic Increased Risk to Cancer. US EPA. Research
Triangle Park, North Carolina. US Government Printing Office. Washington, DC © 1984.
3. Clinical Diagnostic Tests Manual. Quest Diagnositics Lab, Inc. Los Angeles, CA. Review of Clinical Tests of a diagnosed Morgellon’s Patient (M-3) of Dr. Edward Spencer, Neurologist and Dr. Hildegarde Staninger, Industrial Toxicologist/IH & Doctor of Integrative Medicine. © December 2007.
Note: On December 17, 2007 Dr. Hildegarde Staninger’s international environmental best seller text, The Comprehensive Handbook of Hazardous Materials: Regulations, Monitoring, Handling and Safety (under former name Sacarello) was added to the reference text for the new Federal OSHA Standard – 1910.1200 Hazard Communication Standard for Small Businesses. The text was published by Lewis Publishers/CRC Press, Inc. Boca Raton, FL © 1994 and is a reference text for Hazardous Materials and Regulations in 94 libraries throughout the world. It is the standard text for Industrial Hygiene and Environmental Health degree programs for the University of Wisconsin, Old Dominion University and many others.